Speaking Bio - Mosaic Design Labs Colorimetric Assay Instrument
Mosaic Design Labs is a US-based biomedical instrumentation development firm, specializing in combining deep knowledge of biological science with a wide range of engineering expertise in embedded systems, mechanical, microfluidic, and software fields. Having previously worked on diverse projects in life sciences, healthcare, lab automation, and computational modeling platforms, the company offers a comprehensive range of development services. One of their notable achievements is the development of a benchtop instrument that can conduct multiplexed real-time colorimetric nucleic acid amplification assays.
Mosaic Design Labs in the spotlight with Torizon and Toradex
Spencer Sawyer
Manufacturing Engineer
Mosaic Design Labs worked with us to understand our needs and design a lab instrument that fit our QC and R&D workflows. Mosaic combines hardware and software development with deep experience in the biomedical sciences. Mosaic recommended Toradex for the instrument, and a key feature for us was the ability to use the built-in OTA tools to support instruments across the entire fleet.
Mosaic Design Labs’ Journey with Torizon and Toradex
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Addressing the Pain Points
Mosaic sought to create a benchtop device capable of performing concurrent, real-time colorimetric amplification of multiple nucleic acids. They needed to maximize hardware development efficiency, reduce time to market, and find a simple remote update solution to develop an instrument that would offer isothermal incubation for LAMP reactions (loop-mediated isothermal amplification) and simultaneously detect changes in optical absorbance across 48 samples. -
The Challenge of Improving Hardware Development Efficiency
Selecting hardware is more than just meeting hardware specifications. For Mosaic Design Labs, it involved prioritizing the availability of long-term supported hardware and utilizing a set of carrier board development tools to accelerate the development process. Toradex’s offerings proved to be valuable resources for creating custom designs. -
Overcoming the Challenge of Time-to-Market and Updates with Torizon Ecosystem
The complete software stack, from the OS to over-the-air updates, was the major turning point in the decision. Mosaic needed to iterate fast and, even more, they needed to be capable of updating the application with the device in the field. That way, the Torizon Ecosystem and Platform Services provided this and more with Torizon OS (formerly TorizonCore), Device Monitoring dashboards, and a VS Code extension. Then, Mosaic could deploy new features quickly, reducing time to market and costs, and being able to deliver solutions to its clients quickly and seamlessly.
The Torizon Cloud provided an end-to-end solution whereby Toradex hardware and software could be deployed and monitored via a remote platform for in-field updates and proactive device monitoring.
Frankie Myers
Founder and Principal,
Mosaic Design Labs
Positive Results Faster with Toradex and Torizon
Frankie Myers
Founder and Principal,
Mosaic Design Labs
Toradex has a robust ecosystem of partners, support tools, and software to support hardware and software development.
We used the pre-built Qt Debian container for Torizon, which helped us get up and running with a Qt C++ application and touchscreen GUI very quickly.
Frankie Myers
Founder and Principal,
Mosaic Design Labs
Frankie Myers
Founder and Principal,
Mosaic Design Labs
The Visual Studio Code extension simplified image packaging and over-the-air deployment via Torizon Cloud Services, especially for engineers with minimal embedded Linux experience.
Mosaic’s Realtime Colorimetric Assay Instrument Featuring Toradex
Apalis iMX6
- Torizon OS
- Small form factor System on Module
- Up to four Cortex-A9 1.0 GHz processors
- Peak frequency of 800 MHz
- 3D GPU, h.264 encoder and decoder
- High-speed interfaces including CAN, UART, I2C, USB, PCIe, SATA, and many more
- Direct Breakout™
Colorimetric Key Aspects
- Optical specimen block assembly design based around a Peltier thermoelectric module
- Motorized lid mechanism design
- Custom mixed-signal PCBA design
- Firmware developed in C++/Qt with a touchscreen UI built in QML
- Backend database development and web UI for data visualization
- Finite element modeling of thermal performance
- REST API for automation control
- Experimental bench characterization of thermal and optical performance
- Temperature and optical calibration standards and automated calibration routine
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